California Science and Technology University (CSTU) is a C Corporation established in September 2011 by Silicon Valley technology leaders who saw the need for a university focusing on teaching the practical new technology technologies not taught at traditional colleges. Silicon Valley is the center of innovation and where many of the latest technologies originate. The fast-pace development of new technologies also created a strong need for professionals to learn new skills to support these developments without giving up current jobs. CSTU sought to fill this need.

CSTU was approved for operation in April 2016. In May 2017, two entrepreneurs joined the CSTU, and brought in additional funding to support CSTU to expand further. Over the years, the institution retired several non-degree programs but retained its focus as a provider of technology related education. Currently, CSTU offers three (3) programs each of which produced their first graduates in 2018. CSTU graduated its first students from the Master of Business Administration (MBA) and the Master of Science in Computer Systems and Engineering (MSCSE) programs in February 2018. The Emerging Technology Training Program produced its first graduate in April 2018.